Author

H. K. Donnelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Approach:statistical model· 1

Frequent Co-Authors

A. V. Misharin· 2 shared B. D. Singer· 2 shared H. Abdala-Valencia· 2 shared L. Sichizya· 2 shared R. A. Grant· 2 shared R. G. Wunderink· 2 shared Z. LuiD· 2 shared A. Bharat· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. V. Misharin

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19

R. A. Grant, T. A. Poor, L. Sichizya, E. Diaz, J. I. Bailey, S. Soni, K. J. Senkow, X. G. Perez-Leonor, H. Abdala-Valencia, Z. Lu, H. K. Donnelly, R. M. Tighe, J. W. Lomasney, R. G. Wunderink, B. D. Singer, , The NU SCRIPT Investigators

The paper shows that prolonged exposure to lung-derived cytokines in COVID-19 patients activates microglia, and corticosteroids reduce this inflammatory response.

JCI Insight · Mar 19, 2024Peer-reviewedImmunology

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

R. A. Grant, L. Morales-Nebreda, N. S. Markov, S. Swaminathan, E. R. Guzman, D. A. Abbott, H. K. Donnelly, A. Donayre, I. A. Goldberg, Z. M. Klug, N. Borkowski, Z. Lu, H. Kihshen, Y. Politanska, L. Sichizya, , The NU SCRIPT Study Investigators

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Nature · Jan 11, 2021Peer-reviewedImmunology