Author

L. Sichizya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

A. V. Misharin· 6 shared G. S. Budinger· 5 shared H. Abdala-Valencia· 5 shared Z. LuiD· 5 shared A. C. McQuattie-Pimentel· 4 shared N. Joshi· 4 shared S. Watanabe· 4 shared B. D. Singer· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

A. V. Misharin

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6 papers

Recent·Most cited

Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19

R. A. Grant, T. A. Poor, L. Sichizya, E. Diaz, J. I. Bailey, S. Soni, K. J. Senkow, X. G. Perez-Leonor, H. Abdala-Valencia, Z. Lu, H. K. Donnelly, R. M. Tighe, J. W. Lomasney, R. G. Wunderink, B. D. Singer, , The NU SCRIPT Investigators

The paper shows that prolonged exposure to lung-derived cytokines in COVID-19 patients activates microglia, and corticosteroids reduce this inflammatory response.

bioRxiv · Jul 28, 2023Immunology

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

R. A. Grant, L. Morales-Nebreda, N. S. Markov, S. Swaminathan, E. R. Guzman, D. A. Abbott, H. K. Donnelly, A. Donayre, I. A. Goldberg, Z. M. Klug, N. Borkowski, Z. Lu, H. Kihshen, Y. Politanska, L. Sichizya, , The NU SCRIPT Study Investigators

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Nature · Jan 11, 2021Peer-reviewedImmunology

Resetting proteostasis with ISRIB prevents pulmonary fibrosis

S. Watanabe, N. S. Markov, Z. Lu, R. Piseaux Aillon, S. Soberanes, C. E. Runyan, Z. Ren, R. A. Grant, M. Maciel, H. Abdala-Valencia, Y. Politanska, K. Nam, L. Sichizya, H. G. Kihshen, N. Joshi, , A. V. Misharin

ISRIB reduces pulmonary fibrosis severity in young and old mice by modulating stress response signaling in alveolar epithelial cells.

bioRxiv · Feb 26, 2020 · PreprintImmunology

Single-cell RNA-seq reveals spatially restricted multicellular fibrotic niches during lung fibrosis

N. Joshi, S. Watanabe, R. Verma, R. P. Jablonski, C.-I. Chen, P. Cheresh, P. A. Reyfman, A. C. McQuattie-Pimentel, L. Sichizya, A. S. Flozak, C. J. Gottardi, C. M. Cuda, H. Perlman, M. Jain, D. W. Kamp, , A. V. Misharin

The paper identifies monocyte-derived alveolar macrophages as causally linked to fibrosis in lung tissue through autocrine signaling and fibroblast activation.

European Respiratory Journal · Jan 1, 2020Peer-reviewedImmunology

Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in aged mice

C. E. Runyan, L. C. Welch, E. Lecuona, M. Shigemura, L. Amarelle, H. Abdala-Valencia, N. Joshi, Z. Lu, K. Nam, N. S. Markov, A. C. McQuattie-Pimentel, R. Piseaux-Aillon, Y. Politanska, L. Sichizya, S. Watanabe, , A. V. Misharin

bioRxiv · Nov 7, 2019Immunology

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

A. C. McQuattie-Pimentel, Z. Ren, N. Joshi, S. Watanabe, T. Stoeger, M. Chi, Z. Lu, L. Sichizya, R. Piseaux, C.-I. Chen, S. Soberanes, P. A. Reyfman, J. M. Walter, K. R. Anekalla, J. M. Davis, , G. S. Budinger

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.

bioRxiv · Jul 29, 2019 · PreprintImmunology