Author

R. M. Tighe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2

Frequent Co-Authors

A. V. Misharin· 3 shared R. I. Cumming· 3 shared A. Birukova· 2 shared A. T. Vose· 2 shared E. Diaz· 2 shared H. Abdala-Valencia· 2 shared J. I. Bailey· 2 shared K. J. Senkow· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

A. V. Misharin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tissue-resident alveolar macrophages reduce O3-induced inflammation via MerTK mediated efferocytosis

M. A. Guttenberg, A. T. Vose, A. Birukova, K. Lewars, R. I. Cumming, M. C. Albright, J. I. Mark, C. J. Salazar, S. Swaminathan, Z. Yu, Y. V. Sokolenko, E. Bunyan, M. J. Yaeger, M. B. Fessler, L. G. Que, , R. M. Tighe

This study shows tissue-resident alveolar macrophages reduce O3-induced inflammation by clearing apoptotic cells via MerTK-mediated efferocytosis in mice and humans.

bioRxiv · Nov 6, 2023 · PreprintImmunology

Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

J. I. Bailey, C. H. Puritz, K. J. Senkow, N. S. Markov, E. Diaz, E. Jonasson, Z. Yu, S. Swaminathan, Z. Lu, S. Fenske, R. A. Grant, H. Abdala-Valencia, R. J. Mylvaganam, J. Miller, R. I. Cumming, , M. A. Sala

The paper identifies profibrotic monocyte-derived alveolar macrophages and neutrophil recruitment as drivers of lung fibrosis in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.

bioRxiv · Jul 30, 2023Immunology

Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19

R. A. Grant, T. A. Poor, L. Sichizya, E. Diaz, J. I. Bailey, S. Soni, K. J. Senkow, X. G. Perez-Leonor, H. Abdala-Valencia, Z. Lu, H. K. Donnelly, R. M. Tighe, J. W. Lomasney, R. G. Wunderink, B. D. Singer, , The NU SCRIPT Investigators

The paper shows that prolonged exposure to lung-derived cytokines in COVID-19 patients activates microglia, and corticosteroids reduce this inflammatory response.

bioRxiv · Jul 28, 2023Immunology

Allergic Asthma Responses Are Dependent on Macrophage Ontogeny

R. M. Tighe, A. Birukova, Y. Malakhau, Y. Kobayashi, A. T. Vose, V. Chandramohan, J. M. Cyphert-Daly, R. I. Cumming, H. F. Kirshner, P. R. Tata, J. L. Ingram, M. D. Gunn, L. G. Que, Y.-R. A. Yu

This study shows that altering macrophage ontogeny after homeostasis affects allergic airway responses to house dust mites.

bioRxiv · Feb 16, 2023 · PreprintImmunology

TLR5 participates in the TLR4 receptor complex and biases towards MyD88-dependent signaling in environmental lung injury

S. Hussain, C. C. Johnson, J. Sciurba, X. Meng, V. P. Stober, C. Liu, J. Cypher-Daly, K. Bulek, W. Qian, A. Solis, Y. Sakamachi, C. Trempus, J. J. Aloor, K. Gowdy, W. M. Foster, , S. Garantziotis

This study shows TLR5 associates with TLR4 and biases its signaling toward MyD88 in lung injury responses to LPS, hyaluronan, and O3.

bioRxiv · Oct 3, 2019Immunology