Author

L. Morales-Nebreda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. D. Singer· 4 shared H. Abdala-Valencia· 4 shared K. A. Helmin· 3 shared M. A. Torres Acosta· 3 shared Y. Politanska· 3 shared N. S. Markov· 2 shared S. E. Weinberg· 2 shared A. Bharat· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

B. D. Singer

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Author profile →

4 papers

Recent·Most cited

AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress

M. A. Torres Acosta, N. Mambetsariev, C. P. R. Flores, K. A. Helmin, Q. Liu, A. M. Joudi, L. Morales-Nebreda, J. Gurkan, K. Cheng, H. Abdala-Valencia, S. E. Weinberg, B. D. Singer

This study shows AMPK is necessary for Treg cell adaptation to metabolic stress in tumors and lung injury but not for baseline immune homeostasis.

bioRxiv · Nov 29, 2023 · PreprintImmunology

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

R. A. Grant, L. Morales-Nebreda, N. S. Markov, S. Swaminathan, E. R. Guzman, D. A. Abbott, H. K. Donnelly, A. Donayre, I. A. Goldberg, Z. M. Klug, N. Borkowski, Z. Lu, H. Kihshen, Y. Politanska, L. Sichizya, , The NU SCRIPT Study Investigators

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Nature · Jan 11, 2021Peer-reviewedImmunology

Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

L. Morales-Nebreda, K. A. Helmin, N. S. Markov, R. Piseaux, M. A. Torres Acosta, H. Abdala-Valencia, Y. Politanska, B. D. Singer

This study shows that aging impairs Treg cell function during recovery from influenza pneumonia, with transcriptional and DNA methylation changes contributing to reduced reparative capacity in aged mice.

bioRxiv · Jun 5, 2020Immunology

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

K. A. Helmin, L. Morales-Nebreda, M. A. Torres Acosta, K. R. Anekalla, S.-Y. Chen, H. Abdala-Valencia, Y. Politanska, P. Cheresh, M. Akbarpour, E. M. Steinert, S. E. Weinberg, B. D. Singer

This study shows that maintenance DNA methylation, regulated by Uhrf1, is essential for Treg cell development and stability of their suppressive function.

bioRxiv · Feb 3, 2020Immunology