Author

The NU SCRIPT Study Investigators

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ziyan LuiD· 3 shared Alexander V. MishariniD· 2 shared Alvaro DonayreiD· 2 shared Anna E. PawlowskiiD· 2 shared Benjamin David SingeriD· 2 shared Catherine A. GaoiD· 2 shared Chiagozie Ifeoma PickensiD· 2 shared G. R. Scott BudingeriD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Ziyan LuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pathogen-specific host responses define distinct pneumonia endotypes in the human lung

Nikolay S. Markov, Marcin Możejko, Vijeeth Guggilla, Małgorzata Łazȩcka, Helen K. Donnelly, Alvaro Donayre, Samuel W. Fenske, Alec Peltekian, Bruno Puczko-Szymański, Paulina Szymczak, Adam Izdebski, Lucy Luo, Karolina J. Senkow, Luisa Cusick, Zhan Yu, , The NU SCRIPT Study Investigators

This study identifies distinct pneumonia endotypes based on pathogen-specific host responses in the lung, linking them to clinical outcomes and suggesting personalized treatment strategies.

bioRxiv · May 14, 2026 · PreprintImmunology

A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Nikolay S. Markov, Ziyou Ren, Karolina J. Senkow, Rogan A. Grant, Catherine A. Gao, Elizabeth S. Malsin, Lango Sichizya, Hermon G. Kihshen, Kathryn A. Helmin, Milica Jovisic, Jason M Arnold, Xóchitl G. Pérez-Leonor, Hiam Abdala‐Valencia, Suchitra Swaminathan, Julu Nwaezeapu, , Karen M. Ridge

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

Nature Immunology · Aug 13, 2024Peer-reviewedSystems Biology

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

R. A. Grant, L. Morales-Nebreda, N. S. Markov, S. Swaminathan, E. R. Guzman, D. A. Abbott, H. K. Donnelly, A. Donayre, I. A. Goldberg, Z. M. Klug, N. Borkowski, Z. Lu, H. Kihshen, Y. Politanska, L. Sichizya, , The NU SCRIPT Study Investigators

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Nature · Jan 11, 2021Peer-reviewedImmunology