Author

Y. Politanska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2

Frequent Co-Authors

H. Abdala-Valencia· 5 shared N. S. Markov· 4 shared A. V. Misharin· 3 shared B. D. Singer· 3 shared G. S. Budinger· 3 shared L. Morales-Nebreda· 3 shared L. Sichizya· 3 shared Z. LuiD· 3 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

H. Abdala-Valencia

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5 papers

Recent·Most cited

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

R. A. Grant, L. Morales-Nebreda, N. S. Markov, S. Swaminathan, E. R. Guzman, D. A. Abbott, H. K. Donnelly, A. Donayre, I. A. Goldberg, Z. M. Klug, N. Borkowski, Z. Lu, H. Kihshen, Y. Politanska, L. Sichizya, , The NU SCRIPT Study Investigators

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Nature · Jan 11, 2021Peer-reviewedImmunology

Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

L. Morales-Nebreda, K. A. Helmin, N. S. Markov, R. Piseaux, M. A. Torres Acosta, H. Abdala-Valencia, Y. Politanska, B. D. Singer

This study shows that aging impairs Treg cell function during recovery from influenza pneumonia, with transcriptional and DNA methylation changes contributing to reduced reparative capacity in aged mice.

bioRxiv · Jun 5, 2020Immunology

Resetting proteostasis with ISRIB prevents pulmonary fibrosis

S. Watanabe, N. S. Markov, Z. Lu, R. Piseaux Aillon, S. Soberanes, C. E. Runyan, Z. Ren, R. A. Grant, M. Maciel, H. Abdala-Valencia, Y. Politanska, K. Nam, L. Sichizya, H. G. Kihshen, N. Joshi, , A. V. Misharin

ISRIB reduces pulmonary fibrosis severity in young and old mice by modulating stress response signaling in alveolar epithelial cells.

bioRxiv · Feb 26, 2020 · PreprintImmunology

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

K. A. Helmin, L. Morales-Nebreda, M. A. Torres Acosta, K. R. Anekalla, S.-Y. Chen, H. Abdala-Valencia, Y. Politanska, P. Cheresh, M. Akbarpour, E. M. Steinert, S. E. Weinberg, B. D. Singer

This study shows that maintenance DNA methylation, regulated by Uhrf1, is essential for Treg cell development and stability of their suppressive function.

bioRxiv · Feb 3, 2020Immunology

Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in aged mice

C. E. Runyan, L. C. Welch, E. Lecuona, M. Shigemura, L. Amarelle, H. Abdala-Valencia, N. Joshi, Z. Lu, K. Nam, N. S. Markov, A. C. McQuattie-Pimentel, R. Piseaux-Aillon, Y. Politanska, L. Sichizya, S. Watanabe, , A. V. Misharin

bioRxiv · Nov 7, 2019Immunology