Author

H. Khawaja

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Bardelli· 1 shared A. U. Lindner· 1 shared A. Wirth· 1 shared B. Isermann· 1 shared C. Chen· 1 shared C. J. Scott· 1 shared C. Latimer· 1 shared C. Meader· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. Bardelli

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma

J. Yang, J. T. Lim, P. V. Santiago Raj, M. G. Corona, C. Chen, H. Khawaja, Q. Pan, G. D. Paine-Murrieta, R. G. Schnellmann, D. J. Roe, P. C. Gokhale, J. A. DeCaprio, M. Padi

This study identifies pyrvinium pamoate as a potential therapy for Merkel cell carcinoma by targeting Wnt signaling and multiple cancer vulnerabilities.

bioRxiv · Nov 1, 2023Cancer Biology

Bcl-xL is a key mediator of apoptosis following KRASG12C inhibition in KRASG12C mutant colorectal cancer.

H. Khawaja, R. Briggs, C. Latimer, M. Rassel, D. Griffin, L. Hanson, A. Bardelli, F. Di Nicolantonio, S. S. McDade, C. J. Scott, S. Lambe, M. Maurya, A. U. Lindner, J. H. M. Prehn, J. Sousa, , S. Van Schaeybroeck

This study identifies Bcl-xL as a mediator of resistance to KRASG12C inhibitors in colorectal cancer and shows that combining Bcl-xL inhibition with KRASG12C inhibition enhances apoptosis and reduces tumor growth.

bioRxiv · May 10, 2022Cancer Biology

A novel nongenetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosis

S. Gaul, K. Shahzad, R. Medert, I. Gadi, C. Meader, D. Schumacher, A. Wirth, S. Ambreen, S. Fatima, J.-N. Boeckel, H. Khawaja, J. Haas, M. Brune, P. P. Nawroth, B. Isermann, , M. Freichel

This paper establishes a nongenetic mouse model to study atherosclerosis under hyperlipidemia and hyperglycemia conditions and evaluates diet effects on plaque severity.

bioRxiv · Nov 11, 2021 · PreprintPharmacology & Toxicology