H. L. Itell

Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1

The paper identifies SLC35A2 as a host factor that influences HIV-1 tropism by modulating glycosylation, favoring R5 over X4 infection.

Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4+ T cells

This study identifies multiple ISGs that restrict HIV-1 in primary CD4+ T cells through CRISPR-knockout screens and shows their combined protective effect against diverse HIV strains.

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.

High resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies

This study identifies antibody escape pathways for SARS-CoV-2 spike protein using Phage-DMS, revealing variable escape mutations in immunodominant regions and individual epitope targeting differences.

Epitope profiling reveals binding signatures of SARS-CoV-2 immune response and cross-reactivity with endemic HCoVs

This study maps SARS-CoV-2 antibody epitopes and identifies cross-reactive sequences with endemic HCoVs in COVID-19 patients.

Phage-DMS: a comprehensive method for fine mapping of antibody epitopes

Phage-DMS combines immunoprecipitation of phage peptide libraries with deep mutational scanning to fine map antibody epitopes, refining known epitopes for HIV monoclonal antibodies.