G. G. Fouda

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses

This study examines maternal broadly neutralizing antibody (bnAb) specificities in HIV-transmitting and non-transmitting mothers to determine if certain bnAb specificities drive infant transmitted/founder virus selection.

Frequent development of broadly neutralizing antibodies in early life in a large cohort of HIV-infected children

This study finds that HIV-infected children aged 1-3 years develop broadly neutralizing antibodies with breadth comparable to adults, and overall higher than adults, suggesting early life immune advantages for HIV vaccine development.

Vaccine-induced, high magnitude HIV Env-specific antibodies with Fc-mediated effector functions are insufficient to protect infant rhesus macaques against oral SHIV infection

This study tests a vaccine regimen in infant rhesus macaques, finding that Env-specific antibodies with Fc effector functions do not prevent oral SHIV infection.

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.

Maternal alum-adjuvanted recombinant HIV Env vaccine does not enhance autologous virus neutralization in HIV-infected pregnant women

This study evaluates whether maternal HIV Env vaccination boosts autologous virus neutralization in HIV-infected pregnant women, finding no significant enhancement in neutralization potency.