Nicholas Alexander Vitanza

This paper evaluates the combination of B7-H3 CAR T cells and ONC206 against DIPG models, showing enhanced anti-tumor efficacy in vitro and in vivo.

This study identifies CTPS1 as a vulnerability in MYC-driven medulloblastoma and shows that combining CTPS1 and CHK1 inhibition synergistically reduces tumor growth in vivo.

This study shows that H3.1 and H3.3 K27M oncohistones affect chromatin landscapes differently in DMG cells, with H3.1K27M leading to loss of H3K27 trimethylation.