Author

H. M. Sanchez C.

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Ecology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 4 Approach:genetic perturbation / CRISPR· 4 Organism:Drosophila· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. M. Marshall· 6 shared O. S. Akbari· 5 shared I. Antoshechkin· 3 shared A. L. Smidler· 2 shared A. Mondal· 2 shared J. J. Pai· 2 shared M. Li· 2 shared N. P. Kandul· 2 shared

Activity by Year

2016-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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6 shared papersBioengineering

J. M. Marshall

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

MGDrivE 3: A decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillance

A. Mondal, H. M. Sanchez C., J. M. Marshall

MGDrivE 3 simulates mosquito genetic control tools and their epidemiological impacts using a decoupled vector-human framework, incorporating detailed malaria transmission models and surveillance modules.

bioRxiv · Sep 9, 2023Ecology

Eliminating Malaria Vectors with Precision Guided Sterile Males

A. L. Smidler, R. A. Apte, J. J. Pai, M. L. Chow, S. Chen, A. Mondal, H. M. Sanchez C., I. Antoshechkin, J. M. Marshall, O. S. Akbari

This paper develops a precision guided Sterile Insect Technique (pgSIT) for malaria vector control using CRISPR to achieve high male sterility and female lethality in Anopheles gambiae.

bioRxiv · Jul 20, 2023 · PreprintBioengineering

Targeting Sex Determination to Suppress Mosquito Populations

M. Li, N. P. Kandul, R. Sun, T. Yang, E. D. Benetta, D. J. Brogan, I. Antoshechkin, H. M. Sanchez C., Y. Zhan, N. A. DeBeaubien, Y. M. Loh, M. P. Su, C. Montell, J. M. Marshall, O. S. Akbari

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

bioRxiv · Apr 18, 2023Bioengineering

A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae

A. L. Smidler, J. J. Pai, R. A. Apte, H. M. Sanchez C., R. M. Corder, E. J. Gutierrez, N. Thakre, I. Antoshechkin, J. M. Marshall, O. Akbari

This paper develops a genetic population suppression system in Anopheles gambiae mosquitoes using CRISPR to eliminate female offspring, leading to sustained population reduction.

bioRxiv · Aug 30, 2022Bioengineering

Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations

H. M. Sanchez C., J. B. Bennett, S. L. Wu, G. Rasic, O. S. Akbari, J. M. Marshall

The paper models threshold-dependent gene drive systems in Aedes aegypti populations to assess their confineability and reversibility through simulated releases.

BMC Biology · May 12, 2020Peer-reviewedEcology

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

M. Li, T. Yang, N. P. Kandul, M. Bui, S. Gamez, R. Raban, J. Bennett, H. M. Sanchez C., G. C. Lanzaro, H. Schmidt, Y. Lee, J. M. Marshall, O. S. Akbari

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

bioRxiv · May 24, 2019Bioengineering

Overcoming evolved resistance to population-suppressing homing-based gene drives

J. Marshall, A. Buchman, H. M. Sanchez C., O. S. Akbari

This paper develops a mathematical model to assess resistance to CRISPR-Cas9 homing gene drives and proposes a multiplexed gRNA strategy to enhance suppression efficacy.

bioRxiv · Dec 7, 2016Evolutionary Biology