J. M. Marshall

MGDrivE 3: A decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillance

MGDrivE 3 simulates mosquito genetic control tools and their epidemiological impacts using a decoupled vector-human framework, incorporating detailed malaria transmission models and surveillance modules.

Eliminating Malaria Vectors with Precision Guided Sterile Males

This paper develops a precision guided Sterile Insect Technique (pgSIT) for malaria vector control using CRISPR to achieve high male sterility and female lethality in Anopheles gambiae.

Targeting Sex Determination to Suppress Mosquito Populations

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

Mechanical transmission of Dengue Virus by Aedes aegypti may influence disease transmission dynamics during outbreaks

This study shows that Aedes aegypti mosquitoes can mechanically transmit Dengue Virus to mice immediately after biting infected mice, impacting outbreak dynamics and suggesting implications for vector control.

wMel replacement of dengue-competent mosquitoes is robust to near-term climate change

This study assesses the impact of climate change on the effectiveness of wMel Wolbachia-based mosquito control by integrating temperature sensitivity data into a population dynamics model.

A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae

This paper develops a genetic population suppression system in Anopheles gambiae mosquitoes using CRISPR to eliminate female offspring, leading to sustained population reduction.

Close-kin mark-recapture methods to estimate demographic parameters of mosquitoes

This paper extends close-kin mark-recapture methods to mosquitoes, showing they can accurately estimate demographic parameters like population size and mortality rates using genetic data from simulated populations.

Low adenovirus vaccine doses administered to skin using microneedle patches induce better functional antibody immunogenicity as compared to systemic injection.

This study shows that low-dose adenovirus vaccines administered via microneedle patches to the skin induce better functional antibody responses than systemic injection.

Principled simulation of agent-based models in epidemiology

The paper introduces a method to approximate stochastic epidemic models using agent-based simulations, improving speed while converging to exact results in limiting cases.

Household-Level Risk Factors for Aedes aegypti Pupal Density in Guayaquil, Ecuador

This study identifies household-level risk factors for Aedes aegypti pupal density in Guayaquil, Ecuador, finding that large solid item collection and bed canopy use are significant predictors.

Engineered Reproductively Isolated Species Drive Reversible Population Replacement

The paper engineers reproductively isolated species using CRISPR to create threshold-dependent gene drive capabilities in D. melanogaster.

Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations

The paper models threshold-dependent gene drive systems in Aedes aegypti populations to assess their confineability and reversibility through simulated releases.

Vector bionomics and vectorial capacity as emergent properties of mosquito behaviors and ecology

The paper develops a new simulation framework to model mosquito behavior and ecology, showing vectorial capacity emerges from interactions between behavioral algorithms and resource landscapes.

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

Engineered reciprocal chromosome translocations drive high threshold, reversible population replacement in Drosophila