Author

I. Antoshechkin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 5 Organism:Arabidopsis· 4 Approach:experimental assay· 4 Organism:Drosophila· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

O. S. Akbari· 5 shared J. M. Marshall· 4 shared T. Yang· 4 shared H. M. Sanchez C.· 3 shared M. Li· 3 shared O. Akbari· 3 shared A. Buchman· 2 shared A. L. Smidler· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersBioengineering

O. S. Akbari

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Eliminating Malaria Vectors with Precision Guided Sterile Males

A. L. Smidler, R. A. Apte, J. J. Pai, M. L. Chow, S. Chen, A. Mondal, H. M. Sanchez C., I. Antoshechkin, J. M. Marshall, O. S. Akbari

This paper develops a precision guided Sterile Insect Technique (pgSIT) for malaria vector control using CRISPR to achieve high male sterility and female lethality in Anopheles gambiae.

bioRxiv · Jul 20, 2023 · PreprintBioengineering

Efficient Sex Separation by Exploiting Differential Alternative Splicing of a Dominant Marker in Aedes aegypti

S.-C. Weng, I. Antoshechkin, E. Marois, O. S. Akbari

The paper introduces SEPARATOR, a method using sex-specific alternative splicing to enable efficient male-only sex separation in Aedes aegypti for genetic biocontrol.

bioRxiv · Jun 16, 2023 · PreprintBioengineering

Targeting Sex Determination to Suppress Mosquito Populations

M. Li, N. P. Kandul, R. Sun, T. Yang, E. D. Benetta, D. J. Brogan, I. Antoshechkin, H. M. Sanchez C., Y. Zhan, N. A. DeBeaubien, Y. M. Loh, M. P. Su, C. Montell, J. M. Marshall, O. S. Akbari

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

bioRxiv · Apr 18, 2023Bioengineering

Engineered Antiviral Sensor Targets Infected Mosquitoes

E. Dalla Benetta, A. J. Lopez-Denman, H.-H. Li, R. A. Masri, D. J. Brogan, M. Bui, T. Yang, M. Li, M. Dunn, M. J. Klein, S. Jackson, K. Catalan, K. R. Blasdell, P. Tng, I. Antoshechkin, , O. Akbari

The paper develops REAPER, a Cas13-based antiviral sensor that kills infected mosquitoes upon activation by arbovirus infection.

bioRxiv · Jan 27, 2023Bioengineering

A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae

A. L. Smidler, J. J. Pai, R. A. Apte, H. M. Sanchez C., R. M. Corder, E. J. Gutierrez, N. Thakre, I. Antoshechkin, J. M. Marshall, O. Akbari

This paper develops a genetic population suppression system in Anopheles gambiae mosquitoes using CRISPR to eliminate female offspring, leading to sustained population reduction.

bioRxiv · Aug 30, 2022Bioengineering

Engineered Reproductively Isolated Species Drive Reversible Population Replacement

A. Buchman, I. Shriner, T. Yang, J. Liu, I. Antoshechkin, J. M. Marshall, M. W. Perry, O. S. Akbari

The paper engineers reproductively isolated species using CRISPR to create threshold-dependent gene drive capabilities in D. melanogaster.

bioRxiv · Aug 9, 2020Bioengineering

Genome Elimination Mediated by Gene Expression from a Selfish Chromosome

E. Dalla Benetta, I. Antoshechkin, T. Yang, H. Q. M. Nguyen, P. M. Ferree, O. s. Akbari

The paper identifies haploidizer, a gene on a B chromosome in Nasonia vitripennis, that mediates genome elimination and sex conversion through testis-specific expression.

bioRxiv · Oct 4, 2019 · PreprintEvolutionary Biology

Broad Dengue Neutralization in Mosquitoes Expressing an Engineered Antibody

A. Buchman, S. Gamez, M. Li, I. Antoshechkin, S.-H. Lee, S.-W. Wang, C.-H. Chen, M. J. Klein, J.-B. Duchemin, J. E. Crowe, P. N. Paradkar, O. Akbari

This paper develops genetically engineered Aedes aegypti mosquitoes expressing an engineered antibody that broadly neutralizes all four DENV serotypes, significantly reducing viral transmission.

bioRxiv · May 24, 2019Bioengineering