M. Nagai

Asynchronous microexon splicing of LSD1 and PHF21A during neurodevelopment

The paper shows that PHF21A microexon expression precedes LSD1 microexon expression during neurodevelopment, leading to stepwise deactivation of the LSD1-PHF21A complex and unique gene-regulatory roles in neurons.

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota

This study identifies a neuroimmune CGRP-RAMP1 axis that modulates cutaneous adaptive immunity to the microbiota by constraining Type 17 responses and limiting T cell activation.

Protein-coding potential of RNAs measured by potentially translated island scores

This study introduces a PTI score to measure RNA coding potential and finds it correlates with translation and overlaps between coding and noncoding RNAs in different species.

Disruption of nasal bacteria enhances protective immune responses to influenza A virus and SARS-CoV-2 infection in mice

This study shows that disrupting nasal bacteria in mice enhances antibody responses to intranasal influenza and SARS-CoV-2 vaccines, highlighting a role for nasal microbiota in immune induction.

Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

This study identifies structural instability and divergence from conserved residues as causes of intracellular retention of odorant receptors, using computational and experimental methods.

A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes

The paper identifies a novel recombinant porcine EV-G virus with a porcine torovirus PLCP gene replacing viral structural genes, and suggests a potential helper virus role for type 1 recombinant EV-G.