Author

M. Boshart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1

Frequent Co-Authors

F. Bringaud· 3 shared S. Bachmaier· 3 shared M. Biran· 2 shared N. Plazolles· 2 shared O. Villafraz· 2 shared R. Schenk· 2 shared A. Brennand· 1 shared A. Silber· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

F. Bringaud

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

V. Ober, G. B. Githure, Y. Volpato Santos, S. Becker, G. Moya, J. Basquin, F. Schwede, E. Lorentzen, M. Boshart

This study identifies natural nucleosides as activators of PKA in trypanosomatid pathogens, showing they replace cAMP in allosteric regulation through specific binding to CNB domains.

bioRxiv · Oct 24, 2023Biochemistry

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in T. brucei

S. Bachmaier, M. K. Gould, E. Polatoglou, R. Omelianczyk, A. Brennand, M. A. Aloraini, J. C. Munday, D. Horn, M. Boshart, H. P. De Koning

The paper identifies ten cAMP Response Proteins (CARPs) in T. brucei, localized to the flagellum, involved in cAMP pathways, with two shown to bind cAMP.

bioRxiv · Mar 14, 2023 · PreprintMicrobiology

Efficient flavinylation of glycosomal fumarate reductase by its own ApbE domain in Trypanosoma brucei

R. Schenk, S. Bachmaier, F. Bringaud, M. Boshart

This study shows that the ApbE domain of Trypanosoma brucei's glycosomal fumarate reductase catalyzes its own flavinylation, with higher efficiency via intramolecular cis-flavinylation.

bioRxiv · Dec 30, 2020Biochemistry

Fly stage trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in near physiological conditions

O. Villafraz, M. Biran, E. Pineda, N. Plazolles, E. Cahoreau, R. Ornitz, T. Magali, S. Allmann, E. Tetaud, L. Riviere, A. Silber, M. P. Barrett, A. Zikova, M. Boshart, J.-C. Portais, F. Bringaud

This study shows procyclic trypanosomes can use TCA cycle intermediates and glucose catabolites for growth in the fly midgut, expanding their metabolic flexibility.

bioRxiv · Dec 17, 2020Microbiology

Metabolic selection of a homologous recombination mediated loss of glycosomal fumarate reductase in Trypanosoma brucei

M. wargnies, N. Plazolles, R. Schenk, O. Villafraz, J.-W. Dupuy, M. Biran, S. Bachmaier, H. Baudouin, C. Clayton, M. Boshart, F. Bringaud

The paper shows that a deletion event between FRDg and FRDm2 genes is selected in PEPCK knockout cells, leading to a non-functional chimeric gene that reduces growth, suggesting FRD's role in ROS production for parasite differentiation.

bioRxiv · Nov 29, 2020Microbiology