Author

H. Ranga-Prasad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. E. Burke· 3 shared M. K. Rathinaswamy· 3 shared M. L. Jenkins· 3 shared C. K. Yip· 2 shared M. A. Parson· 2 shared N. J. Harris· 2 shared U. Dalwadi· 2 shared B. E. Moeller· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiochemistry

J. E. Burke

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivApr 12, 2023

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

N. J. Harris, M. L. Jenkins, S.-E. Nam…·J. E. Burke

This study identifies the helical domain of p110γ as an allosteric regulator of PI3Kγ activity, showing distinct roles in p110γ-p84 and p110γ-p101 complexes through phosphorylation or nanobody binding.

DOI 10.7554/elife.88058.3

experimental assay

𝕏 PostBluesky

BiochemistrybioRxivJul 29, 2022

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

M. K. Rathinaswamy, M. L. Jenkins, X. Zhang…·J. E. Burke

This study identifies molecular differences between p110γ-p84 and p110γ-p101 complexes that explain their differential activation by GPCRs and Ras.

DOI 10.1016/j.celrep.2023.112172

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintApr 5, 2022

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

M. L. Jenkins, H. Ranga-Prasad, M. A. Parson…·J. E. Burke

This study identifies unique regulatory mechanisms by which oncogenic PIK3CA mutations enhance PI3K membrane recruitment and activation through structural reorientations.

DOI 10.1101/2022.04.05.487205

proteomicsexperimental assay

𝕏 PostBluesky