Author

U. Dalwadi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

C. K. Yip· 5 shared J. E. Burke· 5 shared K. D. Fleming· 4 shared M. K. Rathinaswamy· 4 shared M. L. Jenkins· 3 shared N. J. Harris· 3 shared E. Pardon· 2 shared H. Ranga-Prasad· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersBiochemistry

C. K. Yip

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Author profile →

5 papers

Recent·Most cited

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

N. J. Harris, M. L. Jenkins, S.-E. Nam, M. K. Rathinaswamy, M. A. Parson, H. Ranga-Prasad, U. Dalwadi, B. E. Moeller, E. Sheeky, S. D. Hansen, C. K. Yip, J. E. Burke

This study identifies the helical domain of p110γ as an allosteric regulator of PI3Kγ activity, showing distinct roles in p110γ-p84 and p110γ-p101 complexes through phosphorylation or nanobody binding.

bioRxiv · Apr 12, 2023Biochemistry

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

M. K. Rathinaswamy, M. L. Jenkins, X. Zhang, J. T. Stariha, H. Ranga-Prasad, U. Dalwadi, K. D. Fleming, C. K. Yip, R. L. Williams, J. E. Burke

This study identifies molecular differences between p110γ-p84 and p110γ-p101 complexes that explain their differential activation by GPCRs and Ras.

bioRxiv · Jul 29, 2022Biochemistry

Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation

M. K. Rathinaswamy, U. Dalwadi, K. D. Fleming, C. Adams, J. T. Stariha, E. Pardon, M. Baek, O. Vadas, F. DiMaio, J. Steyaert, S. D. Hansen, C. K. Yip, J. E. Burke

The paper reports the cryo-EM structure of the p110γ-p101 complex, revealing how GPCR activation is mediated through interactions with Gβγ and identifying potential therapeutic targets.

bioRxiv · Jun 1, 2021Biochemistry

Biochemical insight into novel Rab-GEF activity of the mammalian TRAPPIII complex

N. J. Harris, M. L. Jenkins, U. Dalwadi, K. D. Fleming, S.-E. Nam, M. A. Parson, C. K. Yip, J. E. Burke

This study investigates the GEF activity of TRAPPIII and TRAPPII complexes toward Rab GTPases using biochemical and structural methods, revealing Rab specificity and membrane interaction mechanisms.

bioRxiv · Jun 1, 2021Biochemistry

HDX-MS optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

M. K. Rathinaswamy, K. D. Fleming, U. Dalwadi, E. Pardon, N. J. Harris, C. K. Yip, J. Steyaert, J. E. Burke

This paper uses HDX-MS to characterize nanobodies targeting PI3K{gamma} complexes, identifying epitopes and functional effects on lipid kinase activity and GPCR activation.

bioRxiv · Jun 1, 2021Biochemistry