Author

H. S. Earp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

B.-T. Berger· 1 shared C. I. Wells· 1 shared C. R. M. Asquith· 1 shared D. M. Hunter· 1 shared G. Wang· 1 shared J. Jin· 1 shared J. M. Bennett· 1 shared J. M. Elkins· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

B.-T. Berger

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2 papers

Recent·Most cited

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant promoting oncogene activation and tumorous transformation

L. Cai, G. Wang, J. Wang, J. Jin, K.-S. Park, X. Yu, W. Gong, H. S. Earp

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

bioRxiv · Aug 4, 2022Cancer Biology

SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)

C. R. M. Asquith, B.-T. Berger, J. Wan, J. M. Bennett, M. P. East, J. M. Elkins, O. Fedorov, P. H. Godoi, D. M. Hunter, S. Knapp, S. Mueller, C. I. Wells, H. S. Earp, T. M. Willson, W. J. Zuercher

The paper describes SGC-GAK-1, a selective GAK inhibitor, and identifies a related compound that inhibits RIPK2 without GAK activity, providing tools to study GAK and RIPK2 biology.

bioRxiv · Jul 25, 2018Cell Biology