M. P. East

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

The paper identifies and optimizes narrow-spectrum TLK2 inhibitors using QSAR analysis and structural studies.

SMALL MOLECULE CLPP AGONISTS INDUCE SENESCENCE AND ALTER TRAIL-MEDIATED APOPTOTIC RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS

This paper shows that ClpP activators induce senescence in triple-negative breast cancer cells and enhance their sensitivity to TRAIL-mediated apoptosis.

The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and Cilia to Regulate Ciliogenesis and Ciliary Protein Traffic

This study identifies ELMOD1 and ELMOD3 as regulators of ciliogenesis and ciliary protein traffic, with phenotypes similar to ELMOD2 deletion but distinct in their effects on Golgi-ciliary transport.

Design of a GAK/EGFR inhibitor set to interrogate the relationship of EGFR and GAK in chordoma

The paper designs a set of GAK/EGFR inhibitors to study their relationship in chordoma and characterizes their activity in vitro and through target engagement assays.

SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)

The paper describes SGC-GAK-1, a selective GAK inhibitor, and identifies a related compound that inhibits RIPK2 without GAK activity, providing tools to study GAK and RIPK2 biology.

Proteomic Analysis Defines Kinase Taxonomies Specific For Subtypes Of Breast Cancer

The paper uses proteomic analysis to define kinase taxonomies specific to breast cancer subtypes, revealing understudied kinases and their functional integration into signaling subnetworks.