M. Hennig

Cyclic peptide inhibitors stabilize Gq/11 heterotrimers

This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators

The paper determines high-resolution Cryo-EM structures of the human Kv3.1 channel, both apo and ligand-bound, revealing a novel binding site for positive modulators.

Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation

This paper reports the cryo-EM structure of hTRPV4 in an open conformation induced by 4-PDD agonist, revealing molecular mechanisms of activation and providing a template for inhibitor design.

Physical linkage and mate preference generate linkage disequilibrium for behavioral isolation in two parapatric crickets

The paper investigates the sources of linkage disequilibrium in two crickets by analyzing genetic covariance between song and preference traits, finding contributions from physical linkage and pleiotropy.

Demography and selection shape transcriptomic divergence in field crickets

The paper examines transcriptomic divergence in field crickets to disentangle the effects of demography and selection on genetic differentiation.