Author

J. Muehle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

X. Deupi· 2 shared A. Bacchin· 1 shared C.-J. Tsai· 1 shared E. Kostenis· 1 shared F. Andres· 1 shared F. Pamula· 1 shared G. F. Schertler· 1 shared G. Koenig· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

X. Deupi

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2 papers

Recent·Most cited

Cyclic peptide inhibitors stabilize Gq/11 heterotrimers

J. Muehle, M. J. Rodrigues, J. Alenfelder, L. Juergenliemke, R. Guixa-Gonzalez, A. Bacchin, F. Andres, M. Hennig, H. Schihada, M. Cruesemann, G. Koenig, E. Kostenis, G. Schertler, X. Deupi

This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.

bioRxiv · Oct 24, 2023 · PreprintBiochemistry

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit

C.-J. Tsai, J. Marino, R. J. Adaixo, F. Pamula, J. Muehle, S. Maeda, T. Flock, N. M. Taylor, I. Mohammed, H. Matile, R. J. Dawson, X. Deupi, H. Stahlberg, G. F. Schertler

The paper presents a cryo-EM structure of the rhodopsin-Gαi-βγ complex, revealing the C-terminal tail of rhodopsin bound to the Gβ subunit and identifying common anchoring points across G protein-subtype interactions.

bioRxiv · Feb 12, 2019Biochemistry