Author

H. Y. K. Kaan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Chandramohan· 3 shared C. J. Brown· 3 shared C. S. Verma· 3 shared C. W. Johannes· 3 shared S. Kannan· 3 shared T. K. Sawyer· 3 shared A. Sadruddin· 2 shared A. W. Partridge· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

A. Chandramohan

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 25, 2023

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

A. Chandramohan, H. Josien, T. Yuen…·A. W. Partridge

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

DOI 10.1101/2023.02.25.530030

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivPreprintSep 12, 2019

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

S. Kannan, P. G. A. Aronica, S. Ng…·A. Partridge

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

DOI 10.1101/767673

protein sequenceexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivMay 21, 2019

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

S. Ng, Y.-C. Juang, A. Chandramohan…·D. P. Lane

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

DOI 10.1021/acsmedchemlett.0c00022

humanproteomics

𝕏 PostBluesky