Author

Y.-C. Juang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. W. Partridge· 2 shared S. Ng· 2 shared A. Chandramohan· 1 shared A. Sadruddin· 1 shared A. Stoeck· 1 shared B. Henry· 1 shared C. J. Brown· 1 shared C. S. Verma· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

A. W. Partridge

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2 papers

Recent·Most cited

bioPROTACs establish RAS as a degradable target and provide novel RAS biology insights

S. Lim, R. Khoo, Y.-C. Juang, P. Gopal, H. Zhang, C. Yeo, K. M. Peh, J. Teo, S. Ng, B. Henry, A. W. Partridge

The paper demonstrates that RAS proteins can be degraded using bioPROTACs and provides insights into the functional consequences of RAS degradation and mutant susceptibility.

bioRxiv · Jun 26, 2020 · PreprintCancer Biology

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

S. Ng, Y.-C. Juang, A. Chandramohan, H. Y. K. Kaan, A. Sadruddin, T. Y. Yuen, F. J. Ferrer, X. E. C. Lee, L. Xi, C. W. Johannes, C. J. Brown, S. Kannan, P. G. Aronica, N. Berglund, C. S. Verma, , D. P. Lane

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

bioRxiv · May 21, 2019Biochemistry