Author

H.-J. Cha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. Lee· 4 shared C. P. Hong· 2 shared E.-J. Kwon· 2 shared J. Kim· 2 shared Y.-J. Kim· 2 shared A. Adpaikar· 1 shared B. K. Koo· 1 shared B. Kang· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

H. Lee

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sequential genetic, epigenetic alterations in human pluripotent stem cells for recurrent abnormality

Y.-J. Kim, B. Kang, S. Kweon, S. Oh, D. Kim, D. Gil, H. Lee, J. Kim, J. H. Ju, T.-Y. Roh, C. P. Hong, H.-J. Cha

The paper investigates genetic and epigenetic changes in human pluripotent stem cells during in vitro culture and identifies 20q11.21 copy number gain and epigenetic modifications as key factors in inducing culture-adapted phenotypes.

bioRxiv · Dec 17, 2023 · PreprintCell Biology

Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction

J. Kim, S. Kim, S.-Y. Lee, B.-K. Jo, J.-Y. Oh, E.-J. Kwon, K.-T. Kim, A. Adpaikar, E.-J. Kim, H.-S. Jung, H.-R. Kim, J.-S. Roe, C. P. Hong, J. K. Kim, B. K. Koo, H.-J. Cha

This study shows that partial in vivo reprogramming using OSKM factors induces intestinal regeneration via Ptgs1-driven prostaglandin synthesis, distinct from normal Ptgs2-dependent regeneration.

bioRxiv · Feb 25, 2023 · PreprintCell Biology

Identification of a novel HASPIN inhibitor and its synergism with the PLK1 inhibitor

E.-J. Kwon, K. Mashelkar, J. Seo, Y. Shin, K. Sung, S. C. Jang, S. W. Cheon, H. Lee, B. W. Han, L. S. Jeong, H.-J. Cha

The paper identifies a novel HASPIN inhibitor, LJ4827, and shows its synergistic effect with PLK1 inhibitor BI2536 in lung cancer treatment.

bioRxiv · Sep 1, 2022 · PreprintPharmacology & Toxicology

TPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem Cells

H.-C. Jeong, Y.-H. Go, J.-G. Shin, Y.-J. Kim, M.-G. Cho, D. Gwon, H. S. Cheong, H. Lee, J.-H. Lee, C.-Y. Jang, H. D. Shin, H.-J. Cha

The paper identifies TPX2 amplification in late-passaged hESCs as a driver of mitotic aberrations through transcriptome and genomic analysis.

bioRxiv · Feb 22, 2021 · PreprintCell Biology

Computational drug repositioning of bortezomib to reverse metastatic effect of GALNT14 in lung cancer

O.-S. Kwon, H. Lee, H.-J. Kong, J. E. Park, W. Lee, S. Kang, M. Kim, W. Kim, H.-J. Cha

This study uses in silico drug repositioning to identify bortezomib as an inhibitor of GALNT14-driven lung cancer metastasis, validated through in vitro and in vivo experiments.

bioRxiv · Aug 17, 2018Pharmacology & Toxicology