Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2
H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong
This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.
bioRxiv · May 25, 2021 · PreprintMicrobiology