Citrullination of TDP-43 is a key post-translation modification associated with structural and functional changes and progressive pathology in TDP-43 mouse models and human proteinopathies
Christopher Saunders, Patricia Rocha-Rangel, Rohan Desai, Zainuddin Quadri, Haiying Lui, Jerry B. Hunt, Huimin Liang, Colin B. Rogers, Kevin R. Nash, Phoebe S. Tsoi, Erin L. Abner, Allan Chris M. Ferreon, Josephine C. Ferreon, Christopher Mark Norris, Vladimir Nikolaevich Uversky, , Maj‐Linda B. Selenica
This study identifies citrullination as a novel irreversible post-translational modification of TDP-43 linked to structural changes, aggregation, and pathology in TDP-43 proteinopathies.
bioRxiv · Feb 28, 2025 · PreprintNeuroscience