This study investigates how interactions between RNA and the prion-like domain of hnRNPA1 influence aggregate morphology and infectivity in neurodegenerative diseases.

Biomolecules · Mar 25, 2026Peer-reviewedBiochemistry

Tubulin transforms Tau and -synuclein condensates from pathological to physiological

Lathan Lucas, Phoebe S. Tsoi, My Diem Quan, Kyoung‐Jae Choi, Josephine C. Ferreon, Allan Chris M. Ferreon

This study shows tubulin modulates Tau and synuclein condensates from pathological to physiological by promoting microtubule interactions and preventing aggregation.

Nature Communications · Mar 3, 2026Peer-reviewedBiophysics

Citrullination of TDP-43 is a key post-translation modification associated with structural and functional changes and progressive pathology in TDP-43 mouse models and human proteinopathies

Christopher Saunders, Patricia Rocha-Rangel, Rohan Desai, Zainuddin Quadri, Haiying Lui, Jerry B. Hunt, Huimin Liang, Colin B. Rogers, Kevin R. Nash, Phoebe S. Tsoi, Erin L. Abner, Allan Chris M. Ferreon, Josephine C. Ferreon, Christopher Mark Norris, Vladimir Nikolaevich Uversky, , Maj‐Linda B. Selenica

This study identifies citrullination as a novel irreversible post-translational modification of TDP-43 linked to structural changes, aggregation, and pathology in TDP-43 proteinopathies.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience