An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites
Alfred Amambua‐Ngwa, Katrina A. Button-Simons, Xue Li, Sudhir Kumar, Katelyn M. Vendrely, Marco Ferrari, Lisa A. Checkley, Meseret T. Haile, Douglas A. Shoue, Marina McDew‐White, Sarah M. Tindall, Ann N. Reyes, Elizabeth Delgado, Haley Dalhoff, James K. Larbalestier, , Timothy J. C. Anderson
This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.
bioRxiv · May 26, 2022 · PreprintGenomics