David J. Conway

The paper identifies large deletion variants in the PIMMS43 gene of Plasmodium falciparum and shows their geographic frequency variation and potential vector-specific selection.

The paper investigates whether variation in multiplication rates of Plasmodium falciparum isolates under competitive conditions is determined by their intrinsic potential, finding a strong correlation with exponential growth rates.

The paper compares transcript levels of invasion ligand genes in Malaysian and Gambian Plasmodium falciparum isolates, finding regional differences in eba175, eba181, and Rh2b expression.

The paper tracks malaria parasite lineages using de novo mutations in Plasmodium falciparum genomes from community infections in The Gambia, identifying recent mutations and transmission patterns.

The paper analyzes amplicon sequencing data from 17,384 Plasmodium falciparum samples in West Africa to characterize antimalarial resistance patterns and their geographic distribution.

The paper investigates how geographical variation influences the adaptive evolution of Plasmodium falciparum mutations that counteract sickle cell trait protection.

The paper analyzes old Plasmodium falciparum genomes to study malaria parasite adaptation over 50 years, finding strong positive selection at surface protein loci and changes in allele frequencies.

The paper examines intrinsic multiplication rates of Plasmodium falciparum in Malaysian clinical isolates, finding no significant difference compared to African isolates, suggesting no adaptation to low transmission settings.

This study compares Plasmodium falciparum multiplication rates between hospital and community infections, finding higher rates in hospital isolates and a positive correlation with parasitaemia.

The paper genotypes PIEZO1 STR alleles in malaria cases and controls, finding a modest protective effect of E756del against malaria.

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

The paper investigates the association between host sickle cell haemoglobin and parasite genetic variation in malaria severity, finding that parasite alleles linked to HbS show strong linkage disequilibrium and frequency covariation with HbS.

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

This study uses dual transcriptome analysis to identify host and parasite gene expression associated with severe malaria in Gambian children, showing parasite load explains most human gene expression differences but only a third of parasite gene differences.

The paper estimates parasite load dynamics in malaria to identify host resistance mechanisms, finding novel roles for proteases and detrimental effects of interferon response.

The paper identifies a structural variant in GYPA and GYPB genes associated with reduced risk of severe malaria in sub-Saharan African populations.