Author

Ann N. Reyes

Texas Biomedical Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:plant (other)· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Approach:experimental assay· 1

Frequent Co-Authors

Timothy J. C. AndersoniD· 5 shared Ashley M. VaughaniD· 4 shared François Henry NosteniD· 4 shared Ian H. CheesemaniD· 4 shared Katrina A. Button-SimonsiD· 4 shared Lisa A. CheckleyiD· 4 shared Meseret T. HaileiD· 4 shared Michael T. FerdigiD· 4 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersGenomics

Timothy J. C. AndersonORCID

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Author profile →

5 papers

Recent·Most cited

Malaria parasite population genomics during an elimination program in Eastern Myanmar

Xue Li, Grace A. Arya, Aung Myint Thu, Jordi Landier, Daniel M. Parker, Gilles Delmas, Ann N. Reyes, Khin Maung Lwin, Kanlaya Sriprawat, François Henry Nosten, Timothy J. C. Anderson

This study analyzes malaria parasite population genomics during an elimination program in Myanmar, finding genetic depauperation, localized transmission, and a dominant kelch13-R561H genotype in 2020.

bioRxiv · May 21, 2025 · PreprintGenomics

Using a P. falciparum genetic cross to dissect the relative contributions of pfcrt and plasmepsin II/III to piperaquine response-related traits

John Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann N. Reyes, Rupam Tripura, , Michael T. Ferdig

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

bioRxiv · Jun 6, 2023 · PreprintGenomics

An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites

Alfred Amambua‐Ngwa, Katrina A. Button-Simons, Xue Li, Sudhir Kumar, Katelyn M. Vendrely, Marco Ferrari, Lisa A. Checkley, Meseret T. Haile, Douglas A. Shoue, Marina McDew‐White, Sarah M. Tindall, Ann N. Reyes, Elizabeth Delgado, Haley Dalhoff, James K. Larbalestier, , Timothy J. C. Anderson

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

bioRxiv · May 26, 2022 · PreprintGenomics

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

Katelyn M. Vendrely, Xue Li, Sudhir Kumar, Elizabeth Delgado, Lisa A. Checkley, Douglas A. Shoue, Ann N. Reyes, Biley A. Abatiyow, Meseret T. Haile, Rupam Tripura, Thomas Julian Peto, Dysoley Lek, Katrina A. Button-Simons, Stefan H. I. Kappe, Mehul Dhorda, , Tim Anderson

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

iScience · Mar 16, 2022Peer-reviewedGenomics

Bulk segregant analysis reveals environment x genotype interactions determining malaria parasite growth

Sudhir Kumar, Xue Li, Marina McDew‐White, Ann N. Reyes, Elizabeth Delgado, Abeer Sayeed, Meseret T. Haile, Biley A. Abatiyow, Spencer Y. Kennedy, Nelly M. Camargo, Lisa A. Checkley, Katelyn V. Brenneman, Katrina A. Button-Simons, Manoj T. Duraisingh, Ian H. Cheeseman, , Tim Anderson

The paper uses bulk segregant analysis to identify genetic loci affecting malaria parasite growth in different media, finding EBA-140 as a key gene involved in media-dependent fitness.

bioRxiv · Sep 12, 2020 · PreprintGenetics