Targeted shedding of extracellular membrane proteins by induced protease recruitment
Zi W. Yao, Fangzhu Zhao, Kun Miao, Trenton M. Peters-Clarke, Yun Zhang, Snehal D. Ganjave, Ángel L. Vázquez-Maldonado, Wu Yw, Kaan S. Kumru, Hammam Jumaa, Kevin K. Leung, James A. Wells
This paper develops Shedders, bispecific antibodies that recruit ADAM10 to induce ectodomain shedding of cell surface proteins, demonstrating efficacy in depleting LAG-3 and identifying new targets for therapeutic intervention.
bioRxiv · Feb 18, 2026 · PreprintBioengineering