Kun Miao

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

This paper develops Shedders, bispecific antibodies that recruit ADAM10 to induce ectodomain shedding of cell surface proteins, demonstrating efficacy in depleting LAG-3 and identifying new targets for therapeutic intervention.

This study uses advanced imaging techniques to analyze polyQ aggregates in live neurons, revealing their growth dynamics and compartmentalization in Huntington's Disease.

This paper develops LIPTACs, LDLR-targeting chimeras that enhance lysosomal delivery and cytotoxicity for cancer treatment by combining eTPD and ADC strategies.

This paper introduces VISTA, a label-free vibrational imaging technique that achieves high-resolution imaging of biological structures with 82 nm resolution and enables unbiased, high-throughput tissue analysis.