Glutamate as a co-agonist for acid-sensing ion channels to aggravate ischemic brain damage
Ke Lai, Iva Pritišanac, Zhen-Qi Liu, Han-Wei Liu, Li-Na Gong, Mingxian Li, Jian‐Fei Lu, Xin Qi, Tian‐Le Xu, Julie Deborah Forman-Kay, Haibo Shi, Lu‐Yang Wang, Shankai Yin
This study identifies glutamate as a co-agonist for acid-sensing ion channels (ASICs) that worsens ischemic brain damage, and presents a small molecule inhibitor that targets this interaction without affecting NMDARs.
bioRxiv · Feb 17, 2024 · PreprintNeuroscience