NeurosciencebioRxivPreprint
Glutamate as a co-agonist for acid-sensing ion channels to aggravate ischemic brain damage
Ke Lai, Iva Pritišanac, Zhen-Qi Liu…·Shankai Yin
This study identifies glutamate as a co-agonist for acid-sensing ion channels (ASICs) that worsens ischemic brain damage, and presents a small molecule inhibitor that targets this interaction without affecting NMDARs.
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