Potent Cas9 inhibition in bacterial and human cells by new anti-CRISPR protein families
Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcı́a, Nadia Amrani, Hannah E. Lou, Ildar V. Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, Erik J. Sontheimer
The paper identifies and characterizes two new anti-CRISPR protein families that inhibit type II-C Cas9 systems, showing potent inhibition of NmeCas9 and cross-species activity.
bioRxiv · Jun 20, 2018 · PreprintMolecular Biology