Ildar V. Gainetdinov

The paper shows that endogenous siRNAs have much broader regulatory effects on host mRNAs in Drosophila simulans testis compared to Drosophila melanogaster.

This study shows pachytene piRNAs predominantly cleave hundreds of transcripts but only significantly alter the steady-state abundance of a minority, suggesting their evolutionary retention is driven by a few critical targets.

The paper shows that Drosophila males produce Su(Ste) piRNAs through 5'-to-3' phased biogenesis triggered by maternally deposited piRNAs, and this process is bypassed when mothers are XXY.

This study shows PIWI-clade Argonaute proteins can cleave transposon transcripts with mismatches, making them more effective against mutating transposons than AGO-clade Argonautes.

This study shows that terminal modifications like 2'-O-methylation and trimming protect piRNAs from decay, while complementarity affects miRNA stability in mice and flies.

The paper shows that A-MYB activates TCFL5, which is essential for meiosis and spermiogenesis in placental mammals, and its loss causes sterility.

This study identifies a conserved piRNA locus, pi6, essential for male mouse fertility and embryo viability by regulating sperm function through mRNA cleavage.

This study identifies Armitage as a protein linking piRNA amplification in nuage to phased piRNA production on mitochondria in Drosophila.

The paper shows Maelstrom represses canonical transcription in piRNA clusters, enabling Rhi to initiate piRNA precursor transcription.

The paper proposes a unified mechanism for piRNA biogenesis initiated by PIWI proteins, showing it operates across diverse animal species.

The paper identifies and characterizes two new anti-CRISPR protein families that inhibit type II-C Cas9 systems, showing potent inhibition of NmeCas9 and cross-species activity.