Karen L. Maxwell

The paper identifies a novel virus lineage, IME1, found in Dehalococcoides-containing cultures, characterized by features similar to filamentous bacterial viruses.

This paper identifies Aqs1, a phage-encoded protein that inhibits type IV pilus function in multiple Gram-negative bacteria by targeting the PilB ATPase.

The paper identifies prophage-encoded proteins similar to FimU, which replace bacterial cell surface components to defend against phage infection.

The paper identifies DNA glycosylases as antiviral effectors in bacteria, showing their conserved structure and role in defending against phages with modified nucleobases.

The paper identifies a prophage protein that modulates pilus dynamics to prevent phage progeny destruction, enhancing survival through quorum sensing.

This study elucidates the molecular mechanism of BREX anti-phage immunity by showing how BrxX methyltransferase recognizes DNA and forms an immune complex to protect against phage infection.

The paper identifies and characterizes two new anti-CRISPR protein families that inhibit type II-C Cas9 systems, showing potent inhibition of NmeCas9 and cross-species activity.