Alan R. Davidson

A dramatic protein fold switch powers a bactericidal nanomachine

The paper describes a protein fold switch in a bactericidal nanomachine that enables membrane puncture and bactericidal activity.

GNAT: An Interactive Web Tool for Gene Neighbourhood Analysis

GNAT identifies homologues and analyzes genomic neighborhoods to provide interactive visualizations and summary analytics for microbial and viral genomes.

A novel method for detection of Cas9 gRNAs using a fluorophore-labeled DNA oligo

The paper introduces a method for detecting Cas9 gRNAs using fluorophore-labeled DNA oligos to improve gene editing design and targeting efficiency.

Core Defense Hotspots within Pseudomonas aeruginosa are a consistent and rich source of anti-phage defense systems

The paper identifies two highly conserved core defense hotspots in Pseudomonas aeruginosa containing numerous anti-phage systems, including a newly discovered system called Shango.

Potent Cas9 inhibition in bacterial and human cells by new anti-CRISPR protein families

The paper identifies and characterizes two new anti-CRISPR protein families that inhibit type II-C Cas9 systems, showing potent inhibition of NmeCas9 and cross-species activity.