Author

Hannah Klinghoffer

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Anastasia Frank‐KamenetskiiiD· 1 shared Emily LandyiD· 1 shared Jemy Varghese· 1 shared Jeremy A. MorrissetteiD· 1 shared Laurence Crane EisenlohriD· 1 shared Leonardo Huang· 1 shared Scott CannaiD· 1 shared Stephen D. CarroiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Anastasia Frank‐KamenetskiiORCID

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1 paper

Recent·Most cited

Multimodal induction of fulminant HLH by IL-18 includes virus-specific NK immunodeficiency

Jemy Varghese, Emily Landy, Leonardo Huang, Anastasia Frank‐Kamenetskii, Hannah Klinghoffer, Jeremy A. Morrissette, Vinh Dang, Stephen D. Carro, Laurence Crane Eisenlohr, Scott Canna

This study shows IL-18 can induce both hyperinflammation and immunodeficiency in mice depending on the infectious trigger, leading to MAS and poor viral clearance.

bioRxiv · Jul 4, 2025 · PreprintImmunology