Author

Jemy Varghese

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metagenomics· 1

Frequent Co-Authors

Anastasia Frank‐KamenetskiiiD· 2 shared Jeremy A. MorrissetteiD· 2 shared Leonardo Huang· 2 shared Scott CannaiD· 2 shared Vinh DangiD· 2 shared Emily LandyiD· 1 shared Hannah Klinghoffer· 1 shared Laurence Crane EisenlohriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Anastasia Frank‐KamenetskiiORCID

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2 papers

Recent·Most cited

The innate cytokine IL-18 inhibits CNS autoimmunity through preferential activation of protective CD8 T-cells

Jeremy A. Morrissette, Vinh Dang, Leonardo Huang, Jemy Varghese, Zachary R. Lanzar, Anastasia Frank‐Kamenetskii, Scott Canna

This study shows that excess IL-18 protects against CNS autoimmunity by activating CD8 T-cells to suppress CD4 T-cells involved in autoimmune encephalomyelitis.

bioRxiv · Jan 28, 2026 · PreprintImmunology

Multimodal induction of fulminant HLH by IL-18 includes virus-specific NK immunodeficiency

Jemy Varghese, Emily Landy, Leonardo Huang, Anastasia Frank‐Kamenetskii, Hannah Klinghoffer, Jeremy A. Morrissette, Vinh Dang, Stephen D. Carro, Laurence Crane Eisenlohr, Scott Canna

This study shows IL-18 can induce both hyperinflammation and immunodeficiency in mice depending on the infectious trigger, leading to MAS and poor viral clearance.

bioRxiv · Jul 4, 2025 · PreprintImmunology