Scott Canna

This study identifies altered purinergic signaling and CD8+ T cell dysregulation in STAT3 GOF syndrome, showing partial normalization with JAK inhibitors.

The paper develops a comprehensive list of genetic conditions for genomic newborn screening, including 777 conditions associated with 743 genes, for implementation across multiple U.S. states and territories.

This study shows that excess IL-18 protects against CNS autoimmunity by activating CD8 T-cells to suppress CD4 T-cells involved in autoimmune encephalomyelitis.

This study develops a conditional NLRC4 knock-in mouse model that recapitulates the clinical features of autoinflammatory enterocolitis in infants.

This study shows IL-18 can induce both hyperinflammation and immunodeficiency in mice depending on the infectious trigger, leading to MAS and poor viral clearance.

This study shows TLR priming increases NLRC4 expression in murine macrophages, enabling detection of immunoevasive NAIP ligands, while human macrophages lack this response.

This paper introduces causalDeepVASE, a deep-learning method for causal inference that identifies both direct and indirect causal relationships in biological systems, outperforming existing methods in simulated and biological data.