Estradiol regulates local synthesis of synaptic proteome via sex-specific mechanisms.
Pooja Raval, Hannah Rae, Rodrigo R. R. Duarte, Iain A. Watson, Katherine J. Sellers, Kathryn M. C. Pachon, Laura Sichlinger, Timothy R. Powell, Marina V. Yasvoina, Jayanta T. Mukherjee, Stephen J. Moss, Nicholas J. Brandon, Deepak P. Srivastava
This study shows estradiol increases local synaptic protein synthesis in both sexes, but mTOR signaling is sex-specifically required for certain synaptic proteins.
bioRxiv · Dec 17, 2023 · PreprintNeuroscience