Author

Iain A. Watson

King's College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Deepak P. SrivastavaiD· 4 shared Katherine J. SellersiD· 2 shared Pooja RavaliD· 2 shared Rodrigo R. R. DuarteiD· 2 shared Timothy R. PowelliD· 2 shared Anthony Christopher VernoniD· 1 shared Claire TroakesiD· 1 shared Diane P. HangeriD· 1 shared

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4 shared papersNeuroscience

Deepak P. SrivastavaORCID

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4 papers

Recent·Most cited

Overexpression of α-Synuclein Alters The Nanoscopic Organisation of Presynaptic Proteins

Iain A. Watson, Jéssika Cristina Bridi, Diane P. Hanger, Frank Hirth, Deepak P. Srivastava

This study shows that overexpressing α-synuclein variants alters presynaptic protein organisation without changing bouton structure, suggesting a disruption of presynaptic function through the MYCBP2-ELKS axis.

bioRxiv · Oct 10, 2025 · PreprintNeuroscience

Estradiol regulates local synthesis of synaptic proteome via sex-specific mechanisms.

Pooja Raval, Hannah Rae, Rodrigo R. R. Duarte, Iain A. Watson, Katherine J. Sellers, Kathryn M. C. Pachon, Laura Sichlinger, Timothy R. Powell, Marina V. Yasvoina, Jayanta T. Mukherjee, Stephen J. Moss, Nicholas J. Brandon, Deepak P. Srivastava

This study shows estradiol increases local synaptic protein synthesis in both sexes, but mTOR signaling is sex-specifically required for certain synaptic proteins.

bioRxiv · Dec 17, 2023 · PreprintNeuroscience

Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells

Rodrigo R. R. Duarte, Nathaniel D. Bachtel, Marie-Caroline Côtel, Sang Hyuck Lee, Sashika Selvackadunco, Iain A. Watson, Gary A. Hovsepian, Claire Troakes, Gerome D. Breen, Douglas F. Nixon, Robin M. Murray, Nicholas J. Bray, Ioannis Eleftherianos, Anthony Christopher Vernon, Timothy R. Powell, Deepak P. Srivastava

This study identifies NT5C2 as a psychiatric risk gene, showing its role in protein translation and AMPK signaling in neural progenitor cells and Drosophila melanogaster.

Biological Psychiatry · Mar 29, 2019Peer-reviewedNeuroscience

Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3

Katherine J. Sellers, Iain A. Watson, Rahel E. Gresz, Pooja Raval, Deepak P. Srivastava

This study shows that estradiol induces afadin trafficking between synaptic and nuclear compartments, which is required for histone H3 phosphorylation at serine 10.

Neuropharmacology · Sep 27, 2018Peer-reviewedNeuroscience