Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation
Ingvild Bergdal Mestvedt, Eline Menu, Kristine Misund, Tobias Schmidt Slørdahl, Kashif Rasheed, Camilla Wolowczyk, Hanne Hella, Liv Ryan, Therese Standal, Terje Espevik, Maria Yurchenko
This study identifies a SLAMF1-derived peptide, P7N4, that induces apoptosis in multiple myeloma cells by degrading IRF4, enhancing chemotherapy efficacy and showing minimal toxicity to healthy cells.
bioRxiv · May 7, 2025 · PreprintCancer Biology