Hao‐Zheng Li

This study engineers potent avian GPR25 agonists by grafting a fragment from an ostrich CXCL17 gene relic onto other species' CXCL17 proteins, showing enhanced activity at avian GPR25 receptors.

This study identifies functional CXCL17 orthologs in reptiles and shows their loss in birds, using bioinformatics and recombinant protein assays.

This study identifies and functionally characterizes GPR15LG orthologs in fish, showing their conserved signaling with GPR15 and evolutionary origin in ancient fish ancestors.

This study identifies and functionally characterizes CXCL17 orthologs in amphibians, revealing conserved mechanisms of GPR25 receptor activation.

This study identifies and functionally characterizes CXCL17 in cartilaginous fishes, revealing its ancient origin in the CXCL17-GPR25 signaling pathway.

The paper engineers a bamboo-derived peptide ligase with improved activity by modifying its activation mechanism.