Juan-Juan Wang

Engineering potent avian GPR25 agonists using an ostrich CXCL17 gene relic

This study engineers potent avian GPR25 agonists by grafting a fragment from an ostrich CXCL17 gene relic onto other species' CXCL17 proteins, showing enhanced activity at avian GPR25 receptors.

Evolutionary conservation and divergence of CXCL17 orthologs: functional evidence in reptiles and loss in the avian lineage

This study identifies functional CXCL17 orthologs in reptiles and shows their loss in birds, using bioinformatics and recombinant protein assays.

Origin of the GPR15LG-GPR15 signaling axis in ancient fish ancestors

This study identifies and functionally characterizes GPR15LG orthologs in fish, showing their conserved signaling with GPR15 and evolutionary origin in ancient fish ancestors.

Ancestral Origin of the CXCL17-GPR25 System Traced to the Lobe-Finned Fish Latimeria chalumnae

This study identifies a functional CXCL17-GPR25 system in the coelacanth, supporting its evolutionary origin in ancient fishes and transmission to vertebrates.

Identification and Functional Characterization of CXCL17 Orthologs in Amphibians

This study identifies and functionally characterizes CXCL17 orthologs in amphibians, revealing conserved mechanisms of GPR25 receptor activation.

Identification and functional characterization of CXCL17 in cartilaginous fishes reveals an ancient origin of the CXCL17-GPR25 signaling pathway

This study identifies and functionally characterizes CXCL17 in cartilaginous fishes, revealing its ancient origin in the CXCL17-GPR25 signaling pathway.

Identification and functional characterization of two CXCL17 paralogs from zebrafish

This study identifies and functionally characterizes two CXCL17 paralogs in zebrafish, showing they bind and activate GPR25 and induce chemotaxis.

CXCL17 activates three MAS-related G protein-coupled receptors independently of its conserved C-terminal fragment

This study confirms that CXCL17 activates MRGPRX2, MRGPRX1, and MAS1 independently of its C-terminal fragment, unlike its effect on GPR25.

Human CXCL17 Activates and Binds to Fish GPR25 Orthologs

This study shows human CXCL17 activates and binds to fish GPR25 orthologs, suggesting conservation of the CXCL17-GPR25 interaction across vertebrates.