Author

Harlan Robins

Adaptive Biotechnologies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Bryan Howie· 2 shared Mark Klinger· 2 shared Matthew T Noakes· 2 shared Brad Greenfield· 1 shared Brian C Zhang· 1 shared Edward Osborne· 1 shared Erin Calfee· 1 shared Haiyin Chen‐HarrisiD· 1 shared

Activity by Year

2015-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Bryan Howie

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4 papers

Recent·Most cited

TACO: An open, interpretable model for microsecond-scale TCR specificity prediction

Marco Antonio Garcia Noceda, Erin Calfee, Brian C Zhang, Edward Osborne, Brad Greenfield, Mark Klinger, Matthew T Noakes, Bryan Howie, Harlan Robins

TACO predicts TCR specificity against HLA-A*02:01-presented peptides using a statistical model, achieving AUROC 0.67 on held-out data and enabling efficient computational evaluation of TCR-peptide interactions.

bioRxiv · Nov 6, 2026 · PreprintImmunology

HLAResolver: A statistical framework for resolving HLA ambiguity in T-cell response data

Hussein Al-Asadi, Matthew T Noakes, Mark Klinger, Bryan Howie, Harlan Robins

HLAResolver improves HLA resolution in T-cell response data by integrating MIRA responses with NetMHCpan predictions, achieving higher sensitivity and fewer candidate HLAs.

bioRxiv · Nov 3, 2026 · PreprintImmunology

HLA Alleles Imprint Distinct Biases in the Usage Preferences of TCR Vβ segments

Leonardo V. Castorina, Matthew T. Noakes, Lorenzo Pisani, Julia Greissl, Harlan Robins, Haiyin Chen‐Harris, Harus Jabran Zahid

This study identifies HLA allele-specific biases in TCR Vβ usage, showing germline-encoded preferences shape TCR-HLA compatibility and influence TCR-pHLA specificity.

bioRxiv · Mar 19, 2026 · PreprintImmunology

Conjecture: Some auto-immune diseases are caused by the tissue, not a problem with the immune system

Harlan Robins

The paper suggests that some autoimmune diseases may result from tissue defects rather than immune system dysregulation, based on new immune profiling data and existing studies.

bioRxiv · Nov 20, 2015 · PreprintImmunology