Mechanism of spike opening in a mammalian gammacoronavirus
John D. Clarke, Michalina Grabias, Antonio Di Maio, Harley Phlora, Snežana Vasiljević, Sean Anthony Burnap, Rupa Tripathy, Wengang Chai, Weston B. Struwe, Donald J. Benton, Yan Liu, Steve J. Gamblin, Antoni G. Wrobel
This study reports the structures of a mammalian gamma-CoV spike in closed and open conformations, revealing conserved mechanisms of spike dynamics and lipid binding's role in stabilizing the closed state.
bioRxiv · Oct 1, 2026 · PreprintBiochemistry