Author

Wengang Chai

Imperial College LondonORCID 0000-0003-2977-5347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Antonio Di MaioiD· 2 shared Yan LiuiD· 2 shared Antoni G. WrobeliD· 1 shared Claire E. TurneriD· 1 shared Donald J. BentoniD· 1 shared Elita JauneikaiteiD· 1 shared Harley Phlora· 1 shared John D. ClarkeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Antonio Di MaioORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Mechanism of spike opening in a mammalian gammacoronavirus

John D. Clarke, Michalina Grabias, Antonio Di Maio, Harley Phlora, Snežana Vasiljević, Sean Anthony Burnap, Rupa Tripathy, Wengang Chai, Weston B. Struwe, Donald J. Benton, Yan Liu, Steve J. Gamblin, Antoni G. Wrobel

This study reports the structures of a mammalian gamma-CoV spike in closed and open conformations, revealing conserved mechanisms of spike dynamics and lipid binding's role in stabilizing the closed state.

bioRxiv · Oct 1, 2026 · PreprintBiochemistry

M1 protein expression determines niche-specific spread of Streptococcus pyogenes

Kristin K. Huse, Elita Jauneikaite, Nicola N. Lynskey, Lucy Reeves, Mark Reglinski, Matthew K. Siggins, Claire E. Turner, Virginia Tajadura‐Ortega, Yuan Chen, Antonio Di Maio, Wengang Chai, Yan Liu, Lucy Lamb, Shiranee Sriskandan

This study shows that secreted M protein, not cell-surface M protein, is critical for lymphatic survival and systemic infection of Streptococcus pyogenes in mice.

bioRxiv · Feb 11, 2026 · PreprintMicrobiology