Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids
Wai Kit Chan, Shibla Abdulla, Lusi Zhao, Danilo Negro, Victoria M Munro, Sophie R. Thomson, Helen Marshall, Zrinko Kozić, Megan Brown, Michela Barbato, Mariana Beltrán, Neil Cowan Henderson, David Jonathan Price, John O. Mason
This study shows that PAX6 deficiency in human cerebral organoids leads to an increased inhibitory neuron population and altered excitatory/inhibitory ratio due to dysregulated PTN-PTPRZ1 signaling.
Development · Oct 26, 2026Peer-reviewedDevelopmental Biology